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KMID : 0606920110190010102
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Biomolecules & Therapeutics
2011 Volume.19 No. 1 p.102 ~ p.108
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Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga Mice
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Nam Kung-Woo
Noh Jae-Kyu
Kim Su-Kwan
Lee Sung-Jin
Kim Kyeong-Ho
Oh Ki-Bong
Shin Jong-Heon
Mar Woong-Chon
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Abstract
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We examined the effects of essential oil from Thujopsis dolobrata Sieb. et Zucc. var. hondai Makino (EOTD) (Cupressaceae) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Treatment with EOTD twice daily for two weeks ameliorate AD-like skin lesions induced by DNCB (2,4 dinitrochlorobenzene), and clinical scores were reduced to 7.29, 7.07, and 4.5 points in the groups treated with 1.5%, 3.0%, and 6.0% extract (p<0.01) respectively, from the 15.0 score obtained using vehicle. EOTD inhibited the infi ltration of mast cells into the AD-like skin lesion in NC/Nga mice (p<0.01) and also reduced serum histamine and IgE levels (p<0.05). Furthermore, it dose-dependently inhibited the release of beta-hexosaminidase from rat basophilic leukemia RBL 2H3 cells. These results indicate that EOTD reduces AD-like skin lesions by inhibiting the production of IgE and histamine, and, thus, IgE-mediated degranulation.
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KEYWORD
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Thujopsis dolobrata, Atopic dermatitis, Beta-hexosaminidase, NC/Nga mouse, IgE
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